Job Details

Research Specialist A (Department of Neurology)

University Overview

The University of Pennsylvania, the largest private employer in Philadelphia, is a world-renowned leader in education, research, and innovation. This historic, Ivy League school consistently ranks among the top 10 universities in the annual U.S. News & World Report survey. Penn has 12 highly-regarded schools that provide opportunities for undergraduate, graduate and continuing education, all influenced by Penn's distinctive interdisciplinary approach to scholarship and learning. As an employer Penn has been ranked nationally on many occasions with the most recent award from Forbes who named Penn one of America's Best Large Employers in 2023.

Penn offers a unique working environment within the city of Philadelphia. The University is situated on a beautiful urban campus, with easy access to a range of educational, cultural, and recreational activities. With its historical significance and landmarks, lively cultural offerings, and wide variety of atmospheres, Philadelphia is the perfect place to call home for work and play.

The University offers a competitive benefits package that includes excellent healthcare and tuition benefits for employees and their families, generous retirement benefits, a wide variety of professional development opportunities, supportive work and family benefits, a wealth of health and wellness programs and resources, and much more.

Posted Job Title
Research Specialist A (Department of Neurology)

Job Profile Title
Research Specialist A

Job Description Summary
The Research Specialist A position will work on developing and testing nanotechnologies for the treatment of acute brain illnesses, such as ischemic and hemorrhagic stroke. As outlined on our website (www.brennerbioengineeringlab.com), our lab packages drugs and gene therapy vectors into nano-scale carriers (~100 nanometers in diameter), and targets them to the organ and cell types of interest using affinity moieties (e.g., antibodies), cell-hitchhiking, and medical devices. We test these in mouse models of acute critical illness, as well as large animal models, and in ex vivo human organs. We often partner with existing companies and spin out our own start-ups, giving the opportunity to gain experience interacting with industry.

About the Principal Investigator:
Jake Brenner, MD, PhD is an assistant professor (tenure track) and attending at the University of Pennsylvania, where he spends 20% of his time attending in the ICU, and 80% developing technologies for pulmonary & critical care medicine. His nanomedicine lab is developing targeted drug delivery vehicles for acute critical illnesses, such as ARDS, sepsis, and stroke.

Sahily Reyes-Esteves, MD, PhD is an incoming assistant professor (clinician-educator track) within the Brenner group and attending at the University of Pennsylvania, where she spends 20% of his time attending the inpatient and outpatient stroke neurology service, and 80% developing novel brain targeting strategies to treat acute brain illness.

Contact:

Jake Brenner, MD, PhD
Assistant Professor and Attending Physician Pulmonary, Allergy, & Critical Care Division, and
Systems Pharmacology & Translational Therapeutics Department University of Pennsylvania
jake.brenner@gmail.com www.linkedin.com/in/jakebrennermdphd www.brennerbioengineeringlab.com

Sahily Reyes-Esteves, MD, PhD
Assistant Professor and Attending Physician
Division of Stroke Neurology
Department of Neurology
Perelman School of Medicine
Sahily.reyes-esteves@pennmedicine.upenn.edu
http://www.linkedin.com/in/sahilyreyesesteves

Job Description

The applicant will perform a broad range of experiments in mouse work, molecular and cell biology, and pharmacology. The methods will include: mouse models of disease followed by organ harvest; histology of mouse organs; flow cytometry of dissociated mouse organs; pharmacological biodistribution experiments (injecting mice with drugs and harvesting organs to determine drug distribution); production of nanoscale drug carriers according to protocols we already have well worked out; behavioral tests to screen for therapeutic outcomes.

The Principal Investigator will design experiments with the applicant, but the applicant will be expected to troubleshoot these procedures as needed. The applicant will also keep accurate notebooks, perform data analysis, and assist in publication preparation. Additional duties will include assisting in experimental design, and participating in general laboratory activities such as lab meetings, ordering, and maintenance.

Hiring range minimum for this position is $50K.

Salary offers are made based on the candidate's qualifications, experience, skills, and education as they directly relate to the requirements of the position, as well as internal and market factors and grade profile.

Qualifications

• Bachelor of Science and 0 to 1 year of experience or equivalent combination of education and experience is required.
• Experience in one of the following fields preferred: biology, cell biology, biochemistry, molecular biology, pharmacology, chemistry, chemical engineering, bioengineering, or other related fields
• It is preferable for the applicant to have experience with mouse work, including minor surgeries and collection of tissues.
• Additional training will be provided as needed, including teaching of the unique aspects of nanomedicine.

Job Location - City, State
Philadelphia, Pennsylvania

Department / School
Perelman School of Medicine

Pay Range
$44,500.00 - $53,000.00 Annual Rate
Salary offers are made based on the candidate's qualifications, experience, skills, and education as they directly relate to the requirements of the position, and in alignment with salary ranges based on external market data for the job's level. Internal organization and peer data at Penn are also considered.

Equal Opportunity Statement

The University of Pennsylvania is an equal opportunity employer. Candidates are considered for employment without regard to race, color, sex, sexual orientation, religion, creed, national origin (including shared ancestry or ethnic characteristics), citizenship status, age, disability, veteran status or any class protected under applicable federal, state or local law.

Special Requirements
Background checks may be required after a conditional job offer is made. Consideration of the background check will be tailored to the requirements of the job.

University Benefits

• Health, Life, and Flexible Spending Accounts: Penn offers comprehensive medical, prescription, behavioral health, dental, vision, and life insurance benefits to protect you and your family's health and welfare. You can also use flexible spending accounts to pay for eligible health care and dependent care expenses with pre-tax dollars.
  
• Tuition: Take advantage of Penn's exceptional tuition benefits. You, your spouse, and your dependent children can get tuition assistance here at Penn. Your dependent children are also eligible for tuition assistance at other institutions.
  
• Retirement: Penn offers generous retirement plans to help you save for your future. Penn's Basic, Matching, and Supplemental retirement plans allow you to save for retirement on a pre-tax or Roth basis. Choose from a wide variety of investment options through TIAA and Vanguard.
  
• Time Away from Work: Penn provides you with a substantial amount of time away from work during the course of the year. This allows you to relax, take vacations, attend to personal affairs, recover from illness or injury, spend time with family-whatever your personal needs may be.
  
• Long-Term Care Insurance: In partnership with Genworth Financial, Penn offers faculty and staff (and your eligible family members) long-term care insurance to help you cover some of the costs of long-term care services received at home, in the community or in a nursing facility. If you apply when you're newly hired, you won't have to provide proof of good health or be subject to underwriting requirements. Eligible family members must always provide proof of good health and are subject to underwriting.
  
• Wellness and Work-life Resources: Penn is committed to supporting our faculty and staff as they balance the competing demands of work and personal life. That's why we offer a wide variety of programs and resources to help you care for your health, your family, and your work-life balance.
  
• Professional and Personal Development: Penn provides an array of resources to help you advance yourself personally and professionally.
  
• University Resources: As a member of the Penn community, you have access to a wide range of University resources as well as cultural and recreational activities. Take advantage of the University's libraries and athletic facilities, or visit our arboretum and art galleries. There's always something going on at Penn, whether it's a new exhibit at the Penn Museum, the latest music or theater presentation at the Annenberg Center, or the Penn Relays at Franklin Field to name just a few examples. As a member of the Penn community, you're right in the middle of the excitement-and you and your family can enjoy many of these activities for free.
  
• Discounts and Special Services: From arts and entertainment to transportation and mortgages, you'll find great deals for University faculty and staff. Not only do Penn arts and cultural centers and museums offer free and discounted admission and memberships to faculty and staff. You can also enjoy substantial savings on other goods and services such as new cars from Ford and General Motors, cellular phone service plans, movie tickets, and admission to theme parks.
  
• Flexible Work Hours: Flexible work options offer creative approaches for completing work while promoting balance between work and personal commitments. These approaches involve use of non-traditional work hours, locations, and/or job structures.
  
• Penn Home Ownership Services: Penn offers a forgivable loan for eligible employees interested in buying a home or currently residing in West Philadelphia, which can be used for closing costs or home improvements.
  
• Adoption Assistance: Penn will reimburse eligible employees on qualified expenses in connection with the legal adoption of an eligible child, such as travel or court fees, for up to two adoptions in your household.
  

To learn more, please visit: https://www.hr.upenn.edu/PennHR/benefits-pay


Equal Employment Opportunity Statement

The University of Pennsylvania is an equal opportunity employer. Candidates are considered for employment without regard to race, color, sex, sexual orientation, religion, creed, national origin (including shared ancestry or ethnic characteristics), citizenship status, age, disability, veteran status or any class protected under applicable federal, state, or local law.
To apply, visit https://wd1.myworkdaysite.com/en-US/recruiting/upenn/careers-at-penn/job/HUP/Research-Specialist-A--Department-of-Neurology-_JR00104882-1









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